Bionanomatrix was featured as one of the ten emerging technologies of 2009 by MIT's Technology Review. Han Cao has designed a nanofluidic chip that could lower DNA sequencing costs dramatically. By Lauren Gravitz In the corner of the small lab is a locked door with a colorful sign taped to the front: "$100 Genome Room--Authorized Persons Only." BioNanomatrix, the startup that runs the lab, is pursuing what many believe to be the key to personalized medicine: sequencing technology so fast and cheap that an entire human genome can be read in eight hours for $100 or less. With the aid of such a powerful tool, medical treatment could be tailored to a patient's distinct genetic profile. Despite many experts' doubt that whole-genome sequencing could be done for $1,000, let alone a 10th that much, BioNanomatrix believes it can reach the $100 target in five years. The reason for its optimism: company founder Han Cao has created a chip that uses nanofluidics and a series of branching, ever-narrowing channels to allow researchers, for the first time, to isolate and image very long strands of individual DNA molecules. Read More... |